Before my internet decided to have its daily fit, Strider and I ran a few of the Queen's Wrath missions. They aren't to be taken lightly.
The Rundown:
Level 24 - Very Hard
Epic Modifier - Heavily Shielded more aggressive enemies
3 random modifiers - They don't even tell you what they are, you just have to memorize the symbols
Giant Boss Ending Missions - so far that's all we've seen
We did the giant moon boss twice, Rikisi in Old Russia, and Draksis on Venus. There was a lot of hiding and running away to wait for the downed to spawn. We found an exploit on Draksis where you could stand outside the door of the throne room and light him up until he dies. If you enter the throne room, the door locks shut, and you're pretty fucked. I was dying instantly trying to run away.