The only movement issues I have while playing is due to either A: hitting the right key on the keyboard (some of the things require me to use my pinkie, and for some reason, I always have trouble placing it ) or B: driving the Nomad. And that's not a knock on the Nomad, I just suck at it. I'm pretty much as horrible a Nomad driver as I am a Mako driver. I always imagined the crew members drawing straws and whoever loses has to go on mission where my Shepard had to drive.
Here's a video someone did about what bothered him about the animations, and he's pointed out reasons for some of the things that make sense.
One thing he doesn't mention is that the eyeballs have no shading. The white around our eyes is not completely white. There can be slight color on the edges because of blood vessels, and there's shading from the eyelids as well. That shading doesn't really touch the eyeballs in Andromeda. So the creepiness sticks out even more in some lighting situations.
There's also the issue that there's very little body movement. There's occasionally an arm movement, but the dialogue tends to be characters standing almost perfectly still, no arm or head movement. It's like watching two mannequins swaying slightly in the wind talking to each other. We don't hold our heads still to talk, we tilt it, move it, turn slightly to the side, etc. It's puzzling to me how Bioware could go from ME3 animations that aren't perfect, but with subtleties that humans have, to demon-eyed mannequins. I don't know if it can be fixed in a patch (though I really hope so), but it's not going to stop me from playing. I'm enjoying the story and the exploration enough that I'm still going to play. But actual immersion is not going to happen with the animation the way it is.