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Not so much, species 8472 turned their sights on us once the Queen was killed (metaphorically speaking, there hasn't been a resurgence of a new body for the queen at least in STO). They play a pretty big role in a lot of the beginning quests trying to bring down the KDF and Starfleet from within. There's also a whole Expansion dedicated to fighting them (and it sucks, they're just as bad as the Borg when it comes to taking them on sometimes). I'm sure they're still fighting but with the Borg in a weakened state they turned their attentions to us (along with everything else in the fucking galaxy. I've had to fight the Tholians, Dominion (yes, they are still around), Cardassians (yep, still around as well), The Breen, The Xindi, The Hirogen, The Vaadwaur (yes, that species the Voyager team woke up), The Voth, The Iconians, and many other species/factions besides the KDF, Borg, and 8472. It's been literal hell). Could be but not much was ever covered on Unimatrix Zero outside of Voyager. They're called the Cooperative and they're allies with Starfleet through Seven (who makes an appearance in the game acting as sort of an ambassador). All I really know about them is that they're free from the Collective by some means. I'd say it took roughly 40+ years for them to rebuild the conduit hub because they're in vanilla STO and have they're own storyline (they're still trying to invade the Alpha Quadrant). I only say 40+ because I'm not sure how long after Voyager returned home that the events of Nemesis took place (all I know is that Janeway was an Admiral by that time).

Scotty ruined everything.